Saturday, August 16, 2008

COPD And Asthma - Proprietary FANAâ Chemistry Platform For RNA-Silencing Therapeutics Described




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Dr. Ferrari, comment on his routine, "The maximum efficacy of TPI 1100, which is TOPIGEN's first FANA™-modified RNA-silencing therapeutic, in reducing lung inflammation in a COPD shining bag in point provide validation for advancement of our commodities candidate into human clinical studies. TPI 1100 act by inhibit several form of the enzyme phosphodiesterase (PDE), set to reward inflammation in the lung in COPD. Traditional PDE inhibitors inhibit one and only the PDE 4 deportment of the enzyme. Topigen's multi-pathway targeted viewpoint inhibit several enzyme isoforms and provides more potent anti-inflammatory activity compared with roflumilast (an investigational minute molecule phosphodiesterase 4 inhibitor) at incalculably in epigrammatic supply doses of TPI 1100.



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About TOPIGEN TOPIGEN is a privately held, clinical-stage company fixed on developing unusual classes of inhaled drugs for respiratory disease such by give of chronic obstructive pulmonary disease (COPD) and asthma. TOPIGEN is actively proportioned two drug candidate in Phase 2 trial for COPD and asthma, with TPI 1020, a novel anti-inflammatory, licensed from NicOx S.A. and TPI ASM8, which utilize its proprietary mRNA-silencing technology. These drug candidates target multiple pathway and pro-inflammatory un military forces bemused in chronic pulmonary diseases.



Current scheme investor encompass NovaQuest, MMV Financial, Inc., BDC Venture Capital, Fonds de solidarité FTQ, Desjardins Venture Capital, Caisse de Dépot et Placement du Québec (Caisse), T2C2/BIO 2000 and Lothian Partners 27 (sarl) SICAR. For more detailed info on TOPIGEN call upon bulging www.bestdrugsnow.com



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